Spravato Nasal Spray appears both effective and fast acting for treatment of resistant depression, moreover its usage, dosage and safety remains questionable. Researchers published the results of a phase III clinical trial of the drug this week in the American Journal of Psychiatry.
The trial was designed to test the efficacy and safety of spravato nasal spray, the F.D.A approved es-ketamine nasal spray developed by Janssen Pharmaceuticals. The double-blind, active-controlled study included nearly 200 patients across 39 outpatient centers from 2015 to 2017.
Spravato nasal spray adverse effects. Some patients were given es-ketamine nasal spray alongside a traditional oral antidepressant, while the placebo group received saline and a traditional oral antidepressant. The trial lasted for 28 days, and patients were evaluated for symptoms of depression and anxiety at baseline and throughout the course of treatment.
Spravato nasal spray reviews today shows that, those taking es-ketamine showed significantly more improvement than individuals taking placebo. In addition, improvement in symptoms began to take place in as little as 24 hours after the first dose highlighting one of the most exciting aspects of the es-ketamine drug, its fast-acting mechanism is one of the key studies that helped the FDA approve es-ketamine as a treatment for people with resistant depression was this one.
spravato nasal spray dosage for adult
Spravato nasal Spray (es-ketamine). it is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist indicated, in conjunction with an oral antidepressant for the treatment of resistant depression (TRD) in adults besides spravato nasal spray has side effects when its been abuse. Spravato nasal spray adverse effects includes;
-dizziness. -nausea. -sedation. -dissociation. – spinning sensation. -numbness. -anxiety. -lethargy. -increased blood pressure. –vomiting. -feeling drunk.
Spravato nasal spray adverse effects: sedation was evaluated by adverse event reports and the modified observer’s assessment of Alertness/Sedation (MOAA/S). In the MOAA/S, 5 means “responds readily to name spoken in normal tone” and 0 means “no response after painful trapezius squeeze.” Any decrease in MOAA/S from pre-dose is considered to indicate the presence of sedation, such a decrease occurred in a higher number of patients on spravato than placebo during the short-term TRD studies.
Dose-related increases in the incidence of sedation (MOAA/S score <5) were observed in a fixed-dose TRD study [see WARNINGS AND PRECAUTIONS]. Table 5 presents the incidence of sedation (MOAA/S score <5) in a fixed-dose study with adult patients <65 years of age with TRD and a flexible-dose study with patients ≥65 years of age with TRD.
Spravato nasal spray can cause dissociative symptoms (including derealization and depersonalization) and perceptual changes (including distortion of time and space, and illusions). In clinical trials, dissociation was transient and occurred on the day of dosing.
Dissociation was evaluated by adverse event reports and the Clinician-Administered Dissociative States Scale (CADSS). A CADSS total score of more than 4 indicates the presence of dissociative symptoms, moreover such an increase to a score of 4 or more occurred in a higher number of patients on SPRAVATO compared to placebo during the short-term TRD studies. Dose-related increases in the incidence of dissociative symptoms (CADSS total score >4 and change >0) were observed in a fixed-dose TRD study.
Dosage for Spravato
Spravato nasal spray dosage: The starting dose of Spravato nasal spray is 56 mg. Subsequent doses of Spravato are 56 mg or 84 mg administered twice a week for week 1 to week 4, once weekly in week 5 to 8, and every 2 weeks or once weekly in week 9 and after.
What Drugs, Substances, or Supplements Interact with Spravato?
Spravato nasal spray may interact with CNS depressants (e.g benzodiazepines opioids, alcohol), psychostimulants (e.g., amphetamines, methylphenidate, modafanil, armodafinil), and monoamine oxidase inhibitors (MAOIs).